The story ends when the player builds the Fusion Reactor and successfully transmits energy back to Earth, thus solving the planet's energy shortcomings, although the campaign is only finished when the player builds the Corporate Headquarters and expands it with several modules.

The Orbital Watch, a terrorist organization comprised of rebel colonies from the First Wave of Lunar Colonization, serves as the game's main antagonist during the campaign. However, the resource needed to power the Reactor, Helium-3, can only be found on the Moon's surface, and so begins the Lunar Licensing Program.įive Corporations are first allowed into the program, but with the help of Global Union program supervisor Sam Beaumont, the player's corporation is given the chance to participate in the initiative. The campaign's story revolves around Earth's upcoming energy crisis, which can be avoided by the construction of the Fusion Reactor. Sector Projects, although containing their own story elements and missions, are not considered part of the Campaign.

Unlike previous installments of the Anno series, Anno 2205's campaign, the Lunar Licensing Program, is much less restrictive and scripted than previous campaigns, as it is integrated with the Continuous Mode. Anno 2205s campaign sends the player on a quest to reach the Moon to solve Earth's imminent energy crisis